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Soybean agglutinin
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Soybean agglutinin : ウィキペディア英語版
Soybean agglutinin
Soybean agglutinins (SBA) are lectins found in soybeans. It is a family of similar legume lectins. As a lectin, it is an antinutrient that chelates minerals. In human foodstuffs, it is largely eliminated through fermentation and cooking processes.
==Characteristics==
SBAs have a molecular weight of 120 kDa and an isoelectric point near pH 6.0〔http://www.vectorlabs.com/catalog.aspx?catID=249〕 SBA preferentially binds to oligosaccharide structures with terminal α-helix or β-sheet linked N-acetylgalactosamine, and to a lesser extent, galactose residues. Binding can be blocked by substitutions on penultimate sugars, such as fucose attached to the penultimate galactose in blood group B.
SBA binds to intestinal epithelial cells, causing inflammation and Intestinal permeability, and is a major factor in acute inflammation from raw soybean meal fed to animals.〔http://bjournal.com.br/administrator/components/com_jresearch/files/publications/2708.pdf〕

Studies on rats fed SBA had complex changes: With increasing doses of soybean agglutinin, the activities of aspartate aminotransferase linearly increased in plasma and decreased plasma insulin content without decrease in blood glucose levels. Consumption of soybean agglutinin resulted in a depletion of lipid and an overgrowth of small intestine and pancreas in rats. Meanwhile, poor growth of spleen and kidneys was observed in the soybean agglutinin-fed rats. and pancreatic hypertrophy.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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